Home
>
Product
>
Antibody
>
Rabbit Anti-Plakophilin 3 antibody
This gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the cytoskeleton. This protein may act in cellular desmosome-dependent adhesion and signaling pathways. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2014]
Function:
May play a role in junctional plaques.
Subcellular Location:
Nucleus. Cell junction > desmosome. Nuclear and associated with desmosomes.
Tissue Specificity:
Found in desmosomes of most simple and stratified epithelia. Not found in foreskin fibroblasts and various sarcoma-derived cell lines. Beside dendritic reticular cells of lymphatic follicles not found in non-epithelial desmosome-bearing tissues.
Similarity:
Belongs to the beta-catenin family.
Contains 8 ARM repeats.
SWISS:
Q9Y446
Gene ID:
11187
Database links:
Entrez Gene: 11187 Human
Entrez Gene: 5692 Mouse
Entrez Gene: 293619 Rat
Omim: 605561 Human
SwissProt: Q9Y446 Human
SwissProt: Q9QY23 Mouse
Unigene: 534395 Human
Unigene: 350037 Mouse
Unigene: 14963 Rat
|
|