Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene encodes the human ortholog of yeast Vps41 protein which is also conserved in Drosophila, tomato, and Arabidopsis. Expression studies in yeast and human indicate that this protein may be involved in the formation and fusion of transport vesicles from the Golgi. Several transcript variants encoding different isoforms have been described for this gene, however, the full-length nature of not all is known. [provided by RefSeq, Jul 2008]
Function:
Required for vacuolar assembly and vacuolar traffic.
Subcellular Location:
Cytoplasmic face of coated pits and vesicles.
Similarity:
Belongs to the VPS41 family.
Contains 1 CHCR (clathrin heavy-chain) repeat.
Contains 1 RING-type zinc finger.
SWISS:
P49754
Gene ID:
27072
Database links:
Entrez Gene: 420762 Chicken
Entrez Gene: 528654 Cow
Entrez Gene: 27072 Human
Entrez Gene: 23635 Mouse
Entrez Gene: 306991 Rat
Omim: 605485 Human
SwissProt: P49754 Human
SwissProt: Q5KU39 Mouse
Unigene: 592184 Human
Unigene: 27389 Mouse
Unigene: 1289 Rat
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