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Rabbit Anti-ZNF127 antibody
The protein encoded by this gene contains a RING (C3HC4) zinc finger motif and several C3H zinc finger motifs. This gene is intronless and imprinted, with expression only from the paternal allele. Disruption of the imprinting at this locus may contribute to Prader-Willi syndrome. An antisense RNA of unknown function has been found overlapping this gene. [provided by RefSeq, Jul 2008]
Function:
E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.
Tissue Specificity:
Expressed in testis, brain, heart and kidney. Ubiquitously detected at low levels throughout the entire embryo, but expression is highest in the ventricular layers of the brain.
DISEASE:
Expressed at the blastocyst stage and the embryonic days 8-17, as well as in undifferentiated and differentiated embryonic stem cells. Expressed in the arcuate nucleus of both male and female animals. Levels of expression are highest on postnatal days 10 and 12, begin to decline on day 15, and reaches a nadir by days 18 to 22, at which time expression is 10 to 20% of the levels detected at 10 days. The timing of the decline in protein expression correlated with the ages at which arcuate KISS1 and TAC2 have been shown to increase, heralding the onset of puberty.
Similarity:
Contains 3 C3H1-type zinc fingers.
Contains 1 RING-type zinc finger.
SWISS:
Q13064
Gene ID:
7681
Database links:
Entrez Gene: 7681 Human
Entrez Gene: 22652 Mouse
Entrez Gene: 292988 Rat
Omim: 603856 Human
SwissProt: Q13064 Human
SwissProt: Q60764 Mouse
Unigene: 679587 Human
Unigene: 72964 Human
Unigene: 146 Mouse
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