GRIP2 are involved in the targeting of GluR-2 and GluR-3 to the synapse. GRIP1 and GRIP2 are widely expressed in brain, with the highest levels in the cerebral cortex, hippocampus and olfactory bulb. They are both enriched in synaptic plasma and postsynaptic density fractions. GRIP1 is expressed in early development before the expression of AMPA receptors, specifically postnatal days 8-10, while GRIP2 expression parallels that of AMPA receptors during later developmental stages. GRIP1 and GRIP2 may mediate the endocytotic rate of GluR-2 and GluR-3 in response to the phosphorylation of the receptors on Ser 176 by PKC, which is implicated in the induction of cerebellar long-term depression (LTD).
Function:
May play a role as a localized scaffold for the assembly of a multiprotein signaling complex and as mediator of the trafficking of its binding partners at specific subcellular location in neurons.
Subunit:
Interacts with EFNB1, EFNB3, GRIA2, GRIA3, CSPG4 and GRIPAP1. Can form homomultimers and heteromultimers with GRIP1 (By similarity). Interacts with the SLCterminal tail of PRLHR.
Subcellular Location:
Cytoplasm. Membrane; Peripheral membrane protein.
Similarity:
Belongs to the GRIP2 family.
Contains 7 PDZ (DHR) domains.
SWISS:
Q9C0E4
Gene ID:
80852
Database links:
Entrez Gene: 80852 Human
Entrez Gene: 509537 Cow
Entrez Gene: 484638 Dog
Entrez Gene: 243547 Mouse
Entrez Gene: 171571 Rat
SwissProt: Q9C0E4 Human
SwissProt: Q9WTW1 Rat
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