Zinc finger proteins, such as ZNF272, interact with nucleic acids and have diverse functions. The zinc finger domain is a conserved amino acid sequence motif containing 2 specifically positioned cysteines and 2 histidines that are involved in coordinating zinc. Kruppel-related proteins form 1 family of zinc finger proteins. See ZFP93 (MIM 604749) for additional information on zinc finger proteins.[supplied by OMIM, May 2004]
Function:
May be involved in transcriptional regulation.
Subcellular Location:
Nucleus.
Tissue Specificity:
Ubiquitously expressed at low levels. Highest levels are found in pancreas and liver.
Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR.
Similarity:
Belongs to the krueppel C2H2-type zinc-finger protein family.
Contains 11 C2H2-type zinc fingers.
Contains 1 KRAB domain.
SWISS:
Q14592
Gene ID:
10794
Database links:
Entrez Gene: 10794 Human
Omim: 604755 Human
SwissProt: Q14592 Human
Unigene: 99971 Human
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