RASL11A is a member of the small GTPase protein family with a high degree of similarity to RAS (see HRAS, MIM 190020) proteins.[supplied by OMIM, Nov 2008]
Function:
Regulator of rDNA transcription. Acts in cooperation USF/UBTF and positively regulates RNA polymerase I transcription.
Subunit:
Interacts with USF/UBTF.
Subcellular Location:
Nucleus, nucleolus. Associates with rDNA transcription unit throughout the cell cycle.
Tissue Specificity:
Widely expressed. Down-regulated in prostate tumors compared to normal prostate tissue. High levels found in colon tumor and normal colon tissue followed by small intestine, liver, jejunum, ileum, bladder and aorta. Lowest levels observed in endothelial cells.
Similarity:
Belongs to the small GTPase superfamily. Ras family.
SWISS:
Q6T310
Gene ID:
387496
Database links:
Entrez Gene: 387496 Human
Entrez Gene: 68895 Mouse
Entrez Gene: 304268 Rat
Omim: 61483 Human
SwissProt: Q6T310 Human
SwissProt: Q6IMB1 Mouse
SwissProt: Q6IMA3 Rat
Unigene: 192131 Human
Unigene: 266978 Mouse
Unigene: 105901 Rat
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