The glycine-N-acyltransferase protein conjugates glycine with acyl-CoA substrates in the mitochondria. The protein is thought to be important in the detoxification of endogenous and xenobiotic acyl-CoA's. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Function:
Mitochondrial acyltransferase which transfers the acyl group to the N-terminus of glycine. Can conjugate a multitude of substrates to form a variety of N-acylglycines.
Subcellular Location:
Mitochondrion.
Tissue Specificity:
Predominantly expressed in liver (at protein level) and kidney. Down-regulated in hepatocellular carcinoma and other liver cancers.
Similarity:
Belongs to the glycine N-acyltransferase family.
SWISS:
Q6IB77
Gene ID:
10249
Database links:
Entrez Gene: 281787 Cow
Entrez Gene: 483463 Dog
Entrez Gene: 10249 Human
Entrez Gene: 107146 Mouse
Entrez Gene: 293779 Rat
Omim: 607424 Human
SwissProt: Q6IB77 Human
SwissProt: Q91XE0 Mouse
SwissProt: Q5PQT3 Rat
Unigene: 145384 Human
Unigene: 39974 Mouse
Unigene: 21872 Rat
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