This gene encodes a mitochondrial protein that binds leucine tRNAs and other mitochondrial RNAs and plays a role in the regulation of translation. Increased expression of this gene results in decreased mitochondrial leucine tRNA levels. Naturally occurring read-through transcription exists between upstream ATP5J2 (ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F2) and this gene. [provided by RefSeq, Aug 2015]
Function:
Mitochondrial protein implicated in negative regulation of leucine tRNA levels, as well as negative regulation of mitochondria-encoded proteins and COX activity. Affects also the 3'-processing of mitochondrial tRNAs
Subunit:
Associates with mitochondrial leucine tRNAs. Interacts with ELAC2.
Tissue Specificity:
Abundant in testes, skeletal muscle and heart.
Similarity:
Belongs to the PTCD1 family.
Contains 9 PPR (pentatricopeptide) repeats.
SWISS:
O75127
Gene ID:
26024
Database links:
Entrez Gene: 26024 Human
Omim: 614774 Human
SwissProt: O75127 Human
Unigene: 632313 Human
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