Home
>
Product
>
Antibody
>
Rabbit Anti-SLC22A4 antibody
Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. The encoded protein is an organic cation transporter and plasma integral membrane protein containing eleven putative transmembrane domains as well as a nucleotide-binding site motif. Transport by this protein is at least partially ATP-dependent. [provided by RefSeq, Jul 2008]
Function:
Sodium-ion dependent, low affinity carnitine transporter. Probably transports one sodium ion with one molecule of carnitine. Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Relative uptake activity ratio of carnitine to TEA is 1.78. A key substrate of this transporter seems to be ergothioneine (ET).
Subcellular Location:
Membrane.
Tissue Specificity:
Widely expressed. Highly expressed in whole blood, bone marrow, trachea and fetal liver. Weakly expressed in kidney, skeletal muscle, prostate, lung, pancreas, placenta, heart, uterus, spleen and spinal cord. Highly expressed in intestinal cell types affected by Crohn disease, including epithelial cells. Expressed in CD68 macrophage and CD43 T-cells but not in CD20 B-cells. Predominantly expressed in CD14 cells in peripheral blood mononuclear cells.
DISEASE:
Genetic variations in SLC22A4 are a cause of susceptibility to rheumatoid arthritis (RA) [MIM:36300]. It is a systemic inflammatory disease with autoimmune features and a complex genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures.
Similarity:
Belongs to the major facilitator superfamily. Organic cation transporter family.
SWISS:
Q9H015
Gene ID:
6583
Database links:
Entrez Gene: 6583 Human
Entrez Gene: 30805 Mouse
Entrez Gene: 12837 Rat
Omim: 604190 Human
SwissProt: Q9H015 Human
SwissProt: Q9Z306 Mouse
SwissProt: Q9R141 Rat
Unigene: 310591 Human
Unigene: 274590 Mouse
Unigene: 163093 Rat
|
|