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Rabbit Anti-SLC23A1 antibody
The absorption of vitamin C into the body and its distribution to organs requires two sodium-dependent vitamin C transporters. This gene encodes one of the two transporters. The encoded protein is active in bulk vitamin C transport involving epithelial surfaces. Previously, this gene had an official symbol of SLC23A2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]
Function:
Sodium/ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na(+) for each ascorbate.
Subcellular Location:
Membrane.
Tissue Specificity:
Highly expressed in adult small intestine, kidney, thymus, ovary, colon, prostate and liver, and in fetal kidney, liver and thymus.
Post-translational modifications:
Phosphorylated.
Similarity:
Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily.
SWISS:
Q9UHI7
Gene ID:
9963
Database links:
Entrez Gene: 9963 Human
Omim: 603790 Human
SwissProt: Q9UHI7 Human
Unigene: 643467 Human
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