SLC24A6 belongs to a family of potassium-dependent sodium/calcium exchangers that maintain cellular calcium homeostasis through the electrogenic countertransport of 4 sodium ions for 1 calcium ion and 1 potassium ion (Cai and Lytton, 2004 [PubMed 14625281]).[supplied by OMIM, Mar 2008]
Function:
Transports Ca(2+) in exchange for either Li(+) or Na(+), explaining how Li(+) catalyzes Ca(2+) exchange. In contrast to other members of the family its function is independent of K(+).
Subcellular Location:
Cell membrane.
Similarity:
Belongs to the sodium/potassium/calcium exchanger family. SLC24A subfamily.
SWISS:
Q6J4K2
Gene ID:
80024
Database links:
Entrez Gene: 80024 Human
Entrez Gene: 170756 Mouse
Entrez Gene: 498185 Rat
Omim: 609841 Human
SwissProt: Q6J4K2 Human
SwissProt: Q925Q3 Mouse
SwissProt: Q6AXS0 Rat
Unigene: 286194 Human
Unigene: 291070 Mouse
Unigene: 13225 Rat
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