The PFKP gene encodes the platelet isoform of phosphofructokinase (PFK) (ATP:D-fructose-6-phosphate-1-phosphotransferase, EC 2.7.1.11). PFK catalyzes the irreversible conversion of fructose-6-phosphate to fructose-1,6-bisphosphate and is a key regulatory enzyme in glycolysis. The PFKP gene, which maps to chromosome 10p, is also expressed in fibroblasts. See also the muscle (PFKM; MIM 610681) and liver (PFKL; MIM 171860) isoforms of phosphofructokinase, which map to chromosomes 12q13 and 21q22, respectively. Vora (1981) [PubMed 6451249] determined that full tetrameric phophofructokinase enzyme expressed in platelets can be composed of subunits P4, P3L, and P2L2.[supplied by OMIM, Mar 2008]
Function:
Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
Subunit:
Homo- and heterotetramers. Muscle is M4, liver is L4, and red cell is M3L, M2L2, or ML3. A subunit composition with a higher proportion of platelet type subunits is found in platelets, brain and fibroblasts.
Subcellular Location:
Cytoplasm.
Tissue Specificity:
GlcNAcylation decreases enzyme activity.
Similarity:
Belongs to the phosphofructokinase family. Two domains subfamily.
SWISS:
Q01813
Gene ID:
5214
Database links:
Entrez Gene: 5214 Human
Entrez Gene: 56421 Mouse
Entrez Gene: 60416 Rat
Omim: 171168 Human
SwissProt: Q01813 Human
SwissProt: Q9WUA3 Mouse
SwissProt: P47860 Rat
Unigene: 26010 Human
Unigene: 273874 Mouse
Unigene: 2278 Rat
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