The protein encoded by this gene is a system N sodium-coupled amino acid transporter. The encoded protein transports glutamine, asparagine, histidine, serine, alanine, and glycine across the cell membrane, but does not transport charged amino acids, imino acids, or N-alkylated amino acids. Alternative splicing results in multiple transcript variants, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Aug 2013]
Function:
Functions as a sodium-dependent amino acid transporter which countertransport protons. Mediates the saturable, pH-sensitive, and electrogenic cotransport of several neutral amino acids including glycine, asparagine, alanine, serine, glutamine and histidine with sodium.
Subcellular Location:
Cell membrane.
Tissue Specificity:
Predominantly expressed in stomach, brain, liver, lung and intestinal tract.
Similarity:
Belongs to the amino acid/polyamine transporter 2 family.
SWISS:
Q8WUX1
Gene ID:
92745
Database links:
Entrez Gene: 92745 Human
Entrez Gene: 209837 Mouse
Entrez Gene: 192208 Rat
Omim: 300649 Human
SwissProt: Q8WUX1 Human
SwissProt: Q3U1J0 Mouse
SwissProt: A2VCW5 Rat
Unigene: 195155 Human
Unigene: 6055 Mouse
Unigene: 81033 Rat
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