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Rabbit Anti-Secretory phospholipase A2 antibody
The protein encoded by this gene is a member of the phospholipase A2 family (PLA2). PLA2s constitute a diverse family of enzymes with respect to sequence, function, localization, and divalent cation requirements. This gene product belongs to group II, which contains secreted form of PLA2, an extracellular enzyme that has a low molecular mass and requires calcium ions for catalysis. It catalyzes the hydrolysis of the sn-2 fatty acid acyl ester bond of phosphoglycerides, releasing free fatty acids and lysophospholipids, and thought to participate in the regulation of the phospholipid metabolism in biomembranes. Several alternatively spliced transcript variants with different 5' UTRs have been found for this gene.[provided by RefSeq, Sep 2009]
Function:
Thought to participate in the regulation of the phospholipid metabolism in biomembranes including eicosanoid biosynthesis. Catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
Subcellular Location:
Membrane.
Similarity:
Belongs to the phospholipase A2 family.
SWISS:
P14555
Gene ID:
564
Database links:
Entrez Gene: 564 Human
Entrez Gene: 18780 Mouse
Entrez Gene: 29692 Rat
Omim: 172411 Human
SwissProt: P14555 Human
SwissProt: P31482 Mouse
SwissProt: P14423 Rat
Unigene: 461364 Human
Unigene: 4675 Mouse
Unigene: 11346 Rat
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