This gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The protein encoded by this gene is chemotactic for skin-associated memory T lymphocytes. This cytokine may also play a role in mediating homing of lymphocytes to cutaneous sites. It specifically binds to chemokine receptor 10 (CCR10). Studies of a similar murine protein indicate that these protein-receptor interactions have a pivotal role in T cell-mediated skin inflammation. [provided by RefSeq].
Function:
Chemotactic factor that attracts skin-associated memory T-lymphocytes. May play a role in mediating homing of lymphocytes to cutaneous sites. Binds to CCR10.
Subunit:
Monomer, dimer, and tetramer. Heparin avidly promotes oligomerization.
Subcellular Location:
Secreted.
Tissue Specificity:
Testis, thymus, placenta, ovary and skin.
Similarity:
Belongs to the intercrine beta (chemokine CC) family.
SWISS:
Q9Z1X0
Gene ID:
20301
Database links:
Entrez Gene: 100039863 Mouse
Entrez Gene: 100039939 Mouse
Entrez Gene: 100040048 Mouse
Entrez Gene: 20301 Mouse
Entrez Gene: 362505 Rat
SwissProt: Q9Z1X0 Mouse
Unigene: 335946 Mouse
Unigene: 425176 Mouse
Unigene: 484274 Mouse
Unigene: 6660 Mouse
Unigene: 78371 Rat
CCL27是一种CC型趋化因子，又被称为Skinkine，ESkine和CTACK。CCL27基因位于人类染色体9，它与皮肤上归巢的记忆T淋巴细胞有关，并在T细胞介导的皮肤炎症中起着重要的作用。CCL27表达在许多组织，包括性腺，胸腺，胎盘和皮肤。其配体为CCR10,CCL27与接触性软疣病毒编码产生的蛋白质MC148有较高的同源性，但却与人疱疹病毒8型编码产生病毒巨噬细胞炎症蛋白-Ⅱ竞争结合受体CCR10。
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