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Rabbit Anti-TIMM8B antibody
This gene encodes a member of a well-conserved family of proteins with similarity to yeast Tim mitochondrial import proteins. This gene is encoded by a nuclear gene and is transported into the intermembrane space of the mitochondrion. When formed into complexes, these proteins guide membrane-spanning proteins across the mitochondrial intermembrane space before they are added into the mitochondrial inner membrane. This gene is adjacent to succinate dehydrogenase, subunit D (SDHD), in which mutations have been found in affected members of families with hereditary paraganglioma.[provided by RefSeq, Aug 2009]
Function:
Probable mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space (By similarity).
Subunit:
Heterohexamer; possibly composed of 3 copies of TIMM8B and 3 copies of TIMM13, named soluble 70 kDa complex. Associates with the TIM22 complex, whose core is composed of TIMM22 (By similarity).
Subcellular Location:
Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side.
Tissue Specificity:
Ubiquitous, with highest expression in heart, kidney, liver and skeletal muscle.
Similarity:
Belongs to the small Tim family.
SWISS:
Q9Y5J9
Gene ID:
26521
Database links:
Entrez Gene: 26521 Human
Entrez Gene: 30057 Mouse
Entrez Gene: 64372 Rat
Omim: 606659 Human
SwissProt: Q9Y5J9 Human
SwissProt: P62077 Mouse
SwissProt: P62078 Rat
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