CSGlcA-T is a 772 amino acid single-pass type II membrane protein of the golgi apparatus that belongs to the chondroitin N-acetylgalactosaminyltransferase family. Widely expressed and existing as two alternatively spliced isoforms, CSGlcA-T is found at highest levels in small intestine, pancreas and placenta, with lower levels in heart, brain, kidney, and skeletal muscle where it transfers glucuronic acid from UDP-glucuronic acid to N-acetylgalactosamine residues of elongating chondroitin polymers. The gene encoding CSGlcA-T maps to human chromosome 7, which houses over 1,000 genes and comprises nearly 5% of the human genome. Chromosome 7 has been linked to Osteogenesis imperfecta, Pendred syndrome and Lissencephaly.
Function:
Transfers glucuronic acid (GlcUA) from UDP-GlcUA to N-acetylgalactosamine residues on the non-reducing end of the elongating chondroitin polymer. Has no N-acetylgalactosaminyltransferase activity.
Subcellular Location:
Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein (Probable).
Tissue Specificity:
Ubiquitous. Highly expressed in placenta, small intestine and pancreas.
Similarity:
Belongs to the chondroitin N-acetylgalactosaminyltransferase family
SWISS:
Q9P2E5
Gene ID:
5496
Database links:
Entrez Gene: 5496 Human
Entrez Gene: 100910 Mouse
Entrez Gene: 296733 Rat
Omim: 608037 Human
SwissProt: Q9P2E5 Human
Unigene: 647084 Human
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