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Home > Product > Antibody > Rabbit Anti-ROR alpha antibody
NR1F1; Nuclear receptor ROR-alpha; Nuclear receptor RZR-alpha; Nuclear receptor subfamily 1 group F member 1; RAR-related orphan receptor A; Retinoid-related orphan receptor-alpha; Rora; RORA_HUMAN; RZR-ALPHA; RZRA.
Cat:
SL20687R
Species Reactivity：
Human,Mouse,Rat,(predicted: Chicken,Dog,Pig,Cow,Horse,Sheep,)
Immunogen：
KLH conjugated synthetic peptide derived from human ROR alpha:321-420/523
Format：
Liquid
Storage instructions：
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Concentration：
1mg/ml
Clonality：
Polyclonal
Isotype：
IgG
Applications：
WB=1:500-2000ELISA=1:5000-10000not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.
Host：
Rabbit
Product Overview：
Sample: Lane 1: Mouse Cerebrum tissue lysates Lane 2: Mouse Cerebellum tissue lysates Lane 3: Mouse Kidney tissue lysates Lane 4: Mouse Heart tissue lysates Lane 5: Mouse Liver tissue lysates Lane 6: Rat Cerebellum tissue lysates Lane 7: Rat Heart tissue lysatesLane 8: Human HeLa cell lysates Primary: Anti-ROR alpha (SL20687R) at 1/1000 dilutionSecondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilutionPredicted band size: 59 kDaObserved band size: 60 kDa
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Product PDFs
Datasheet:


The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The encoded protein has been shown to interact with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation, as well as with NM23-1, the product of a tumor metastasis suppressor candidate gene. Also, it has been shown to aid in the transcriptional regulation of some genes involved in circadian rhythm. Four transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2014]

Function:
Orphan nuclear receptor. Binds DNA as a monomer to hormone response elements (HRE) containing a single core motif half-site preceded by a short A-T-rich sequence. This isomer binds to the consensus sequence 5'-[AT][TA]A[AT][CGT]TAGGTCA-3'. Regulates a number of genes involved in lipid metabolism such as apolipoproteins AI, APOA5, CIII, CYP71 and PPARgamma, in cerebellum and photoreceptor development including PCP2, OPN1SW, OPN1SM AND ARR3, in circadian rhythm with BMAL1, and skeletal muscle development with MYOD1. Possible receptor for cholesterol or one of its derivatives.

Subunit:
Monomer.

Subcellular Location:
Nucleus.

Tissue Specificity:
Widely expressed in a number of tissues. Expressed in both regulatory T-cells (Treg) and effector T-cells (Teff).

Similarity:
Belongs to the nuclear hormone receptor family. NR1 subfamily.
Contains 1 nuclear receptor DNA-binding domain.

SWISS:
P35398

Gene ID:
6095

Database links:

Entrez Gene: 6095 Human

Omim: 600825 Human

SwissProt: P35398 Human

Unigene: 560343 Human

Unigene: 655155 Human



Picture

Sample:
Lane 1: Mouse Cerebrum tissue lysates
Lane 2: Mouse Cerebellum tissue lysates
Lane 3: Mouse Kidney tissue lysates
Lane 4: Mouse Heart tissue lysates
Lane 5: Mouse Liver tissue lysates
Lane 6: Rat Cerebellum tissue lysates
Lane 7: Rat Heart tissue lysates
Lane 8: Human HeLa cell lysates
Primary: Anti-ROR alpha (SL20687R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 59 kDa
Observed band size: 60 kDa
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