CCL6 (C10) is a small cytokine belonging to the CC chemokine family that has only been identified in rodents. It is a potent chemoattractant of macrophages, but it can also attract B cells, CD4+ lymphocytes and eosinophils. In mice, CCL6 is expressed in cells from neutrophil and macrophage lineages, and can be induced under conditions suitable for myeloid cell differentiation. CCL6 (C10) was originally identified as a transcript that is induced in bone marrow cells upon stimulation of GMCSF. The cell surface receptor for CCL6 is believed to be the chemokine receptor CCR1.
Function:
CCL6(22-95) and CCL6(23-95) are potent chemoattractants.
Subcellular Location:
Secreted.
Tissue Specificity:
Expressed in myelopoietic bone marrow cultures stimulated by GM-CSF.
Similarity:
Belongs to the intercrine beta (chemokine CC) family.
SWISS:
P27784
Gene ID:
20305
Database links:
Entrez Gene: 20305 Mouse
Entrez Gene: 287910 Rat
SwissProt: P27784 Mouse
SwissProt: Q68FP3 Rat
Unigene: 137 Mouse
Unigene: 7857 Rat
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