This gene is a member of the Rab family of small G proteins and plays a role in regulating membrane trafficking between trans-Golgi network (TGN) and recycling endosomes (RE). The encoded protein is involved in the assembly of tight junctions, which are components of the apical junctional complex (AJC) of epithelial cells. The AJC plays a role in forming a barrier between luminal contents and the underlying tissue. Additional functions associated with the protein include endocytic recycling of occludin, regulation of epithelial cell scattering, neuronal regeneration and regulation of neurite outgrowth. Alternately spliced transcript variants have been observed for this gene. A pseudogene associated with this gene is located on chromosome 12. [provided by RefSeq, Jan 2013]
Subunit:
Interacts (GTP-bound form) with MICALL2; competes with RAB8A and is involved in tight junctions assembly. Interacts (GTP-bound form) with MICALL1. Interacts with PRKACA; downstream effector of RAB13 involved in tight junction assembly. Interacts with GRB2; may recruit RAB13 to the leading edge of migrating endothelial cells where it can activate RHOA. Interacts (isoprenylated form) with PDE6D; dissociates RAB13 from membranes. Interacts with CCDC64B/BICDR2. Interacts with LEPROT and LEPROTL1.
Subcellular Location:
Cell junction. tight junction. Cell membrane. Cytoplasmic vesicle membrane. Cytoplasmic tight junctions or associated with vesicles scattered throughout the cytoplasm in cells lacking tight junctions.
Tissue Specificity:
Detected in several types of epithelia, including intestine, kidney, liver and in endothelial cells.
Similarity:
Belongs to the small GTPase superfamily. Rab family.
SWISS:
P51153
Gene ID:
5872
Database links:
Entrez Gene: 514541 Cow
Entrez Gene: 5872 Human
Entrez Gene: 68328 Mouse
Entrez Gene: 81756 Rat
Entrez Gene: 373105 Zebrafish
Omim: 602672 Human
SwissProt: Q58DS5 Cow
SwissProt: P51153 Human
SwissProt: Q5U0A6 Human
SwissProt: Q9DD03 Mouse
SwissProt: P35286 Rat
SwissProt: Q7T3A4 Zebrafish
Unigene: 151536 Human
Unigene: 29355 Mouse
Unigene: 9819 Rat
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