Rabbit Anti-phospho-Aconitase 1 (Ser138) antibody

Home > Product > Antibody > Rabbit Anti-phospho-Aconitase 1 (Ser138) antibody

Aconitase 1 (phospho S138); p-Aconitase 1 (phospho S138); ACO 1; ACO1; ACOC_HUMAN; Aconitase 1 soluble; Aconitase; Aconitase1; Aconitate hydratase; ACONS; Citrate hydro lyase; Citrate hydro-lyase; Cytoplasmic aconitate hydratase; Ferritin repressor protei

Cat:

SL20251R

Species Reactivity：

(predicted: Human,Mouse,Rat,Pig,Rabbit,)

Immunogen：

KLH conjugated synthesised phosphopeptide derived from human Aconitase 1 around the phosphorylation site of Ser138:AD(p-S)LQ

Format：

Liquid

Storage instructions：

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

WB=1:500-2000ELISA=1:5000-10000IHC-P=1:100-500IHC-F=1:100-500ICC=1:100-500IF=1:100-500（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

prev next

Unit:

Price: $256.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
Feedback Wall

Iron metabolism is essential for sustaining mammalian homeostasis. Iron uptake and distribution is a highly regulated process in mammalian cells that is monitored by two iron sensing proteins; iron regulatory protein-1 and -2 (IRP-1 and -2), also known as iron responsive element-binding protein-1 and -2 (IRE–BP-1 and -2) or aconitase 1 and 2. IRP-1 and IRP-2 are important soluble regulatory factors that mediate iron uptake and storage in mammalian cells. They are capable of either repressing translation or enhancing mRNA stability by associating with stem-loop motifs known as iron-responsive elements (IREs). IRPs respond to stress mediators, iron concentration and signaling factors, including nitrogen monoxide, cytokines and hydrogen peroxide.

Function:
Iron sensor. Binds a 4Fe-4S cluster and functions as aconitase when cellular iron levels are high. Functions as mRNA binding protein that regulates uptake, sequestration and utilization of iron when cellular iron levels are low. Binds to iron-responsive elements (IRES) in target mRNA species when iron levels are low. Binding of a 4Fe-4S cluster precludes RNA binding.

Subunit:
Interacts (when associated with the 4Fe-4S) with FBXL5. Interacts with frataxin(81-210).

Subcellular Location:
Cytoplasm.

Similarity:
Belongs to the aconitase/IPM isomerase family.

SWISS:
P21399

Gene ID:
48

Database links:

Entrez Gene: 48 Human

Entrez Gene: 11428 Mouse

Entrez Gene: 50655 Rat

Omim: 100176 Human

SwissProt: P21399 Human

SwissProt: P28271 Mouse

SwissProt: Q63270 Rat

Unigene: 567229 Human

Unigene: 331547 Mouse

Unigene: 35934 Rat

Product Feedback Wall