This gene is a member of the human ARF gene family whose members encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of phospholipase D. The gene products include 5 ARF proteins and 11 ARF-like proteins and constitute one family of the RAS superfamily. The ARF proteins are categorized as class I, class II and class III; this gene is a class II member. The members of each class share a common gene organization. The ARF4 gene spans approximately 12kb and contains six exons and five introns. This gene is the most divergent member of the human ARFs. Conflicting map positions at 3p14 or 3p21 have been reported for this gene. [provided by RefSeq, Jul 2008]
Function:
GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.
Subcellular Location:
Golgi apparatus.
Similarity:
Belongs to the small GTPase superfamily. Arf family.
SWISS:
P3685
Gene ID:
378
Database links:
Entrez Gene: 769725 Chicken
Entrez Gene: 518601 Cow
Entrez Gene: 378 Human
Entrez Gene: 11843 Mouse
Entrez Gene: 595108 Pig
Entrez Gene: 79120 Rat
Omim: 601177 Human
SwissProt: Q3SZF2 Cow
SwissProt: P3685 Human
SwissProt: P61750 Mouse
SwissProt: P61751 Rat
Unigene: 652183 Human
Unigene: 297768 Mouse
Unigene: 35935 Rat
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