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Rabbit Anti-Tristetraprolin/ZFP36 antibody
ZFP36 (ZFP36 Ring Finger Protein) is a Protein Coding gene. Among its related pathways are Spinal Cord Injury and ErbB1 downstream signaling. GO annotations related to this gene include poly(A) RNA binding and enzyme binding. An important paralog of this gene is ZFP36L2.
Function:
mRNA-binding protein involved in post-transcriptional regulation of AU-rich element (ARE)-containing mRNAs. Acts by specifically binding ARE-containing mRNAs and promoting their degradation. Recruits deadenylase CNOT7 (and probably the CCR4-NOT complex) via association with CNOT1. Plays a key role in the post-transcriptional regulation of tumor necrosis factor (TNF). Plays a key role in the post-transcriptional regulation of tumor necrosis factor (TNF).
Subunit:
Interacts (via SLCterminus) with CNOT1.
Subcellular Location:
Nucleus {ECO:0000269|PubMed:15014438}. Cytoplasm {ECO:0000269|PubMed:15014438}. Note=Localizes to stress granules upon energy starvation. phosphorylation by MAPKAPK2 promotes exclusion from stress granules.
Post-translational modifications:
Phosphorylation by MAPKAPK2 increases its stability and binding to 14-3-3 proteins, leading to reduce its ARE affinity leading to inhibition of degradation of ARE-containing transcripts. Phosphorylated upon mitogen stimulation.
Similarity:
Contains 2 C3H1-type zinc fingers.
SWISS:
P26651
Gene ID:
7538
Database links:
Entrez
Gene: 7538 Human
Entrez Gene: 79426 Rat
Omim: 190700 Human
SwissProt: P26651 Human
SwissProt: P47973 Rat
Unigene: 534052 Human
Unigene: 728064 Human
Unigene: 82737 Rat
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