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Rabbit Anti-Topoisomerase I antibody
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus altering the topology of DNA. This gene is localized to chromosome 20 and has pseudogenes which reside on chromosomes 1 and 22. [provided by RefSeq, Jul 2008]
Function:
The reaction catalyzed by topoisomerases leads to the conversion of one topological isomer of DNA to another.
Subcellular Location:
Nucleus, nucleolus. Nucleus, nucleoplasm. Diffuse nuclear localization with some enrichment in nucleoli. On CPT treatment, cleared from nucleoli into nucleoplasm. Sumolyated forms found in both nucleoplasm and nucleoli.
Post-translational modifications:
Sumoylated. Lys-117 is the main site of sumoylation. Sumoylation plays a role in partitioning TOP1 between nucleoli and nucleoplasm. Levels are dramatically increased on camptothecin (CPT) treatment.
DISEASE:
Note=A chromosomal aberration involving TOP1 is found in a form of therapy-related myelodysplastic syndrome. Translocation t(11;20)(p15;q11) with NUP98.
Similarity:
Belongs to the eukaryotic type I topoisomerase family.
SWISS:
P2287
Gene ID:
7150
Database links:
Entrez Gene: 7150 Human
Entrez Gene: 21969 Mouse
Entrez Gene: 64550 Rat
Entrez Gene: 281539 Cow
Omim: 126420 Human
SwissProt: P2287 Human
SwissProt: Q04750 Mouse
SwissProt: Q9WUL0 Rat
Unigene: 472737 Human
Unigene: 712686 Human
Unigene: 217233 Mouse
Unigene: 91572 Rat
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