This gene encodes a serine/threonine kinase which localizes predominantly to the nucleus. Its specific function is unknown; it is possible that phosphorylation of this protein is involved in transcriptional regulation. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6 and expresses two transcript variants. [provided by RefSeq, Jul 2008]
Function:
Seems to be a protein kinase. In vitro it can phosphorylate casein-alpha on serine and threonine residues and histones on serine residues.
Subunit:
The N-terminus interacts with BAG1.
Subcellular Location:
Nuclear
Tissue Specificity:
Monocytes, hepatocytes, epithelial cells, T- and B-lymphocytes.
Similarity:
Belongs to the STK19 family.
SWISS:
Q9JHN8
Gene ID:
5882
Database links:
Entrez Gene: 8859 Human
Entrez Gene: 5882 Mouse
Omim: 604977 Human
SwissProt: P49842 Human
SwissProt: Q9JHN8 Mouse
Unigene: 654371 Human
|
|