This gene is a member of the sauvagine/corticotropin-releasing factor/urotensin I family. It is structurally related to the corticotropin-releasing factor (CRF) gene and the encoded product is an endogenous ligand for CRF type 2 receptors. In the brain it may be responsible for the effects of stress on appetite. In spite of the gene family name similarity, the product of this gene has no sequence similarity to urotensin II. [provided by RefSeq, Jul 2008].
Function:
Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress.
Subunit:
Binds with high affinity to CRF receptors 2-alpha and 2-beta.
Subcellular Location:
Secreted.
Similarity:
Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.
SWISS:
Q96RP3
Gene ID:
90226
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