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Rabbit Anti-phospho-Bik (Thr33) antibody
The protein encoded by this gene is known to interact with cellular and viral survival-promoting proteins, such as BCL2 and the Epstein-Barr virus in order to enhance programed cell death. Because its activity is suppressed in the presence of survival-promoting proteins, this protein is suggested as a likely target for antiapoptotic proteins. This protein shares a critical SH3 domain with other death-promoting proteins, BAX and BAK.
Function:
Accelerates programmed cell death. Association to the apoptosis repressors Bcl-X(L), SHRF1, Bcl-2 or its adenovirus homolog E1B 19k protein suppresses this death-promoting activity. Does not interact with BAX.
Subunit:
Interacts with RHBDL4/RHBDD1.
Subcellular Location:
Endomembrane system; Single-pass membrane protein. Mitochondrion membrane; Single-pass membrane protein. Note=Around the nuclear envelope, and in cytoplasmic membranes.
Post-translational modifications:
Proteolytically cleaved by RHBDL4/RHBDD1. RHBDL4/RHBDD1-induced cleavage is a necessary step prior its degradation by the proteosome-dependent mechanism.
SWISS:
Q13323
Gene ID:
638
Database links:
Entrez Gene: 638 Human
Entrez Gene: 12124 Mouse
Omim: 603392 Human
SwissProt: Q13323 Human
SwissProt: O70337 Mouse
Unigene: 475055 Human
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