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Rabbit Anti-Creatine Kinase M antibody
Creatine kinase (CK), also known as creatine phosphokinase (CPK) or phosphocreatine kinase, is an enzyme expressed by various tissues and cell types. CK catalyses the conversion of creatine and utilizes adenosine triphosphate (ATP) to create phosphocreatine (PCr) and adenosine diphosphate (ADP). This CK enzyme reaction is reversible and thus ATP can be generated from PCr and ADP. In the cells, the "cytosolic" CK enzymes consist of two subunits, which can be either B (brain type) or M (muscle type). There are, therefore, three different isoenzymes: CK-MM, CK-BB and CK-MB.
Clinically, creatine kinase is assayed in blood tests as a marker of damage of CK-rich tissue such as in myocardial infarction (heart attack), rhabdomyolysis (severe muscle breakdown), muscular dystrophy, autoimmune myositides, and acute kidney injury.
Function:
Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa.
Subunit:
Dimer of identical or non-identical chains. With MM being the major form in skeletal muscle and myocardium, MB existing in myocardium, and BB existing in many tissues, especially brain.
Subcellular Location:
Cytoplasm.
Similarity:
Belongs to the ATP:guanido phosphotransferase family.
Contains 1 phosphagen kinase SLCterminal domain.
Contains 1 phosphagen kinase N-terminal domain.
SWISS:
P06732
Gene ID:
1158
Database links:
Entrez Gene: 1158 Human
Entrez Gene: 12715 Mouse
Entrez Gene: 24265 Rat
Omim: 123310 Human
SwissProt: P06732 Human
SwissProt: P07310 Mouse
SwissProt: P00564 Rat
Unigene: 334347 Human
Unigene: 2375 Mouse
Unigene: 10756 Rat
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