This gene encodes a protein subunit that regulates the activity of the serine/threonine phosphatase, protein phosphatase-1. The encoded protein is required for completion of the mitotic cycle and for targeting protein phosphatase-1 to mitotic kinetochores. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Function:
Regulatory subunit of protein phosphatase 1.
Subcellular Location:
Nucleus.
Tissue Specificity:
Widely expressed.
Similarity:
Belongs to the SDS22 family.
Contains 11 LRR (leucine-rich) repeats.
Contains 1 LRRCT domain.
SWISS:
Q15435
Gene ID:
5510
Database links:
Entrez Gene: 424844 Chicken
Entrez Gene: 505297 Cow
Entrez Gene: 477430 Dog
Entrez Gene: 5510 Human
Entrez Gene: 66385 Mouse
Entrez Gene: 301618 Rat
Entrez Gene: 560323 Zebrafish
Omim: 602877 Human
SwissProt: Q3T0W4 Cow
SwissProt: Q15435 Human
SwissProt: Q3UM45 Mouse
SwissProt: Q5HZV9 Rat
SwissProt: Q32PL1 Zebrafish
Unigene: 36587 Human
Unigene: 88704 Mouse
Unigene: 19437 Rat
Unigene: 76971 Zebrafish
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