The protein encoded by this gene is similar to PPAR-gamma coactivator 1 (PPARGC1/PGSLC1), a protein that can activate mitochondrial biogenesis in part through a direct interaction with nuclear respiratory factor 1 (NRF1). This protein has been shown to interact with NRF1. It is thought to be a functional relative of PPAR-gamma coactivator 1 that activates mitochondrial biogenesis through NRF1 in response to proliferative signals. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
Function:
Acts as a coactivator during transcriptional activation of nuclear genes related to mitochondrial biogenesis and cell growth. Involved in the transcription coactivation of CREB and NRF1 target genes.
Subcellular Location:
Nuclear
Tissue Specificity:
Strongly expressed in heart and skeletal muscle, moderately in lung, placenta, intestine, liver, kidney, spleen, thymus, colon and brain. Also expressed in several oncocytic thyroid tumors.
Similarity:
Contains 1 RRM (RNA recognition motif) domain.
SWISS:
Q5VV67
Gene ID:
23082
Database links:
Entrez Gene: 23082 Human
SwissProt: Q5VV67 Human
Unigene: 533551 Human
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