The protein encoded by this gene is membrane-associated and contains five ankyrin repeats, a protein phosphatase-1-interacting domain, and a carboxy-terminal CAAX box domain. Synthesis of the encoded protein is inhibited by transforming growth factor beta-1. The protein may bind to the membrane through its CAAX box domain and may act as a signaling molecule through interaction with protein phosphatase-1. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene.[provided by RefSeq, Feb 2010]
Function:
Regulator of protein phosphatase 1 (PP1) that acts as a positive regulator of pulmonary endothelial cell (EC) barrier function. Involved in PKA-mediated moesin dephosphorylation which is important in EC barrier protection against thrombin stimulation. Promotes the interaction of PPP1CA with RPSA/LAMR1 and in turn facilitates the dephosphorylation of RPSA/LAMR1. Involved in the regulation of endothelial cell filopodia extension. May be a downstream target for TGF-beta1 signaling cascade in endothelial cells.
Subcellular Location:
Cell membrane. Cell membrane. Nucleus. Co-localizes with RPSA/LAMR1 in the cell membrane.
Tissue Specificity:
Highly expressed in vascular endothelium, CNS, lung, spleen, kidney and testis.
Post-translational modifications:
Phosphorylated by PKA and, after PKA priming, by GSK3B. Phosphorylation by GSK3B reduces its association with PP1C and enhances PP1C activity.
Dephosphorylation by its associated PP1C results in enhanced association with PP1C, but reduced PP1C activity.
Similarity:
Contains 5 ANK repeats.
SWISS:
Q96T49
Gene ID:
26051
Database links:
Entrez Gene: 26051 Human
Entrez Gene: 228852 Mouse
Omim: 613275 Human
SwissProt: Q96T49 Human
SwissProt: Q8VHQ3 Mouse
Unigene: 45719 Human
Unigene: 150540 Mouse
Unigene: 485085 Mouse
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