Rabbit Anti-PPP1R1C antibody

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Inhibitor 5 of protein phosphatase 1; IPP5; PP1 inhibitor protein 5; Ppp1r1c; PPR1C_HUMAN; Protein phosphatase 1 regulatory subunit 1A; Protein phosphatase 1 regulatory subunit 1C; protein phosphatase 1, regulatory (inhibitor) subunit 1C.

Cat:

SL19991R

Species Reactivity：

(predicted: Human,Mouse,Rat,Dog,Rabbit,)

Immunogen：

KLH conjugated synthetic peptide derived from human PPP1R1C:1-100/567

Format：

Liquid

Storage instructions：

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ELISA=1:5000-10000IHC-P=1:100-500IHC-F=1:100-500ICC=1:100-500IF=1:100-500（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

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Unit:

Price: $228.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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This gene encodes a cAMP-regulated phosphoprotein. The encoded protein is enriched in the caudate nucleus and cerebellar cortex. A similar protein in mouse may be involved in regulating the effects of dopamine in the basal ganglia. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]

Function:
Isoform 2 may act as a competitive inhibitor of calmodulin-dependent enzymes such as calcineurin in neurons.

Subcellular Location:
Cytoplasm.

Tissue Specificity:
Isoform 2 is expressed in brain. Isoform 1 is present in immature thymocytes (at protein level).

Post-translational modifications:
Phosphorylation at Ser-56 favors interaction with CALM1.
Isoform 1 is methylated by CARM1 in immature thymocytes.

Similarity:
Contains 1 R3H domain.

SWISS:
Q8WVI7

Gene ID:
151242

Database links:

Entrez Gene: 10777 Human

Entrez Gene: 74100 Mouse

Entrez Gene: 363153 Rat

Omim: 605488 Human

SwissProt: Q9UBL0 Human

SwissProt: Q9DCB4 Mouse

Unigene: 475902 Human

Unigene: 71725 Human

Unigene: 297444 Mouse

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