This gene encodes the catalytic subunit of the serine/theonine phosphatase, protein phosphatase-1. The encoded protein is expressed in liver and skeletal muscle tissue and may be involved in regulating glycogen synthesis in these tissues. This gene may be a involved in type 2 diabetes and maturity-onset diabetes of the young. Alternate splicing results in multiple transcript variants that encode the same protein.[provided by RefSeq, Jan 2011]
Function:
Acts as a glycogen-targeting subunit for phosphatase PP1. Facilitates interaction of the PP1 with enzymes of the glycogen metabolism and regulates its activity. Suppresses the rate at which PP1 dephosphorylates (inactivates) glycogen phosphorylase and enhances the rate at which it activates glycogen synthase and therefore limits glycogen breakdown. Its activity is inhibited by PYGL, resulting in inhibition of the glycogen synthase and glycogen phosphorylase phosphatase activities of PP1. Dramatically increases basal and insulin-stimulated glycogen synthesis upon overexpression in hepatocytes.
Subunit:
Interacts with glycogen, PPP1CC catalytic subunit of PP1 and PYGL. Associates with glycogen particles. Forms complexes withdebranching enzyme, glycogen phosphorylase, glycogen synthase and phosphorylase kinase which is necessary for its regulation of PP1 activity (By similarity).
Tissue Specificity:
Highly expressed in liver. Expressed moderately in skeletal muscle and myotubes (at protein level). Expressed predominantly in heart and skeletal muscle. Expressed moderately in liver. Expressed weakly in placenta, lung and kidney.
Similarity:
Contains 1 CBM21 (carbohydrate binding type-21) domain.
SWISS:
Q86XI6
Gene ID:
79660
Database links:
Entrez Gene: 514428 Cow
Entrez Gene: 79660 Human
Entrez Gene: 244416 Mouse
Entrez Gene: 192280 Rat
Omim: 610541 Human
SwissProt: A6QNP3 Cow
SwissProt: Q86XI6 Human
SwissProt: Q8C767 Mouse
SwissProt: Q6IN01 Rat
Unigene: 458513 Human
Unigene: 247126 Mouse
Unigene: 30046 Rat
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