PAIP2 (Poly(A) Binding Protein Interacting Protein 2) is a Protein Coding gene. Among its related pathways are Translational Control and TGF-Beta Pathway. GO annotations related to this gene include mRNA binding and translation repressor activity. An important paralog of this gene is PAIP2B.
Function:
Acts as a repressor in the regulation of translation initiation of poly(A)-containing mRNAs. Its inhibitory activity on translation is mediated via its action on PABPC1. Displaces the interaction of PABPC1 with poly(A) RNA and competes with PAIP1 for binding to PABPC1. Its association with PABPC1 results in disruption of the cytoplasmic poly(A) RNP structure organization.
Subunit:
Interacts with the RRM1-RRM2 and SLCterminus regions of PABPC1 in a 1:1 stoichiometry. Interacts with EIF4A.
Subcellular Location:
Cytoplasm.
Similarity:
Belongs to the PAIP2 family.
SWISS:
Q9BPZ3
Gene ID:
51247
Database links:
Entrez Gene: 416187 Chicken
Entrez Gene: 536619 Cow
Entrez Gene: 51247 Human
Entrez Gene: 67869 Mouse
Entrez Gene: 361309 Rat
Omim: 605604 Human
SwissProt: Q5ZJS6 Chicken
SwissProt: Q3ZC67 Cow
SwissProt: Q9BPZ3 Human
SwissProt: Q9D6V8 Mouse
SwissProt: Q6AXZ0 Rat
Unigene: 396644 Human
Unigene: 126534 Mouse
Unigene: 1073 Rat
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