This gene encodes a sodium and potassium/ proton antiporter that is a member of the solute carrier family 9 protein family. The encoded protein is primarily localized to the trans-Golgi network and is involved in maintaining pH homeostasis in organelles along the secretory and endocytic pathways. This protein may enhance cell growth of certain breast tumors. This gene is part of a gene cluster on chromosome Xp11.23. A pseudogene of this gene is found on chromosome 12. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012]
Function:
Mediates electroneutral exchange of protons for Na(+) and K(+) across endomembranes. May contribute to Golgi volume and cation homeostasis.
Subcellular Location:
Golgi apparatus, trans-Golgi network membrane. Recycling endosome membrane.
Tissue Specificity:
Ubiquitously expressed.
Similarity:
Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
SWISS:
Q96T83
Gene ID:
84679
Database links:
Entrez Gene: 84679 Human
Entrez Gene: 236727 Mouse
Entrez Gene: 317170 Rat
Omim: 300368 Human
SwissProt: Q96T83 Human
SwissProt: Q8BLV3 Mouse
Unigene: 91389 Human
Unigene: 132983 Mouse
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