The yeast heterotetrameric GINS complex is made up of Sld5, Psf1 (GINS1; MIM 610608), Psf2 (GINS2; MIM 610609), and Psf3 (GINS3; MIM 610610). The formation of the GINS complex is essential for the initiation of DNA replication in yeast and Xenopus egg extracts (Ueno et al., 2005 [PubMed 16287864]). See GINS1 for additional information about the GINS complex.[supplied by OMIM, Mar 2008]
Function:
The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS4 is important for GINS complex assembly. GINS complex seems to bind preferentially to single-stranded DNA.
Subcellular Location:
Cytoplasm. Nucleus.
Similarity:
Belongs to the GINS4/SLD5 family.
SWISS:
Q9BRT9
Gene ID:
84296
Database links:
Entrez Gene: 770899 Chicken
Entrez Gene: 482843 Dog
Entrez Gene: 100055757 Horse
Entrez Gene: 84296 Human
Entrez Gene: 109145 Mouse
Entrez Gene: 100738105 Pig
Entrez Gene: 290842 Rat
Entrez Gene: 703350 Rhesus monkey
Entrez Gene: 572562 Zebrafish
Omim: 610611 Human
SwissProt: Q9BRT9 Human
SwissProt: Q99LZ3 Mouse
SwissProt: Q499W2 Rat
Unigene: 656996 Human
Unigene: 27945 Mouse
Unigene: 103411 Rat
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