The protein encoded by this gene is a mitochondrial membrane protein that is responsible for increasing the level of reactive oxygen species (ROS) in cells. The protein also has antimicrobial activity against a variety of bacteria by inducing bacterial membrane breakage. [provided by RefSeq, Nov 2014]
Function:
Induces production of reactive oxygen species (ROS) which are necessary for cell proliferation. May play a role in inducing oxidative DNA damage and replicative senescence.
Subcellular Location:
Mitochondrion membrane.
Tissue Specificity:
Up-regulated in a number of cancer cell lines when compared to a normal lung fibroblast cell line.
Similarity:
Belongs to the MGR2 family.
SWISS:
P60602
Gene ID:
140823
Database links:
Entrez Gene: 140823 Human
SwissProt: P60602 Human
Unigene: 472564 Human
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