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Rabbit Anti-POMZP3 antibody
This gene appears to have resulted from a fusion of DNA sequences derived from 2 distinct loci, specifically through the duplication of two internal exons from the POM121 gene and four 3' exons from the ZP3 gene. The 5' end of this gene is similar to the 5` coding region of the POM121 gene which encodes an integral nuclear pore membrane protein. However, the protein encoded by this gene lacks the nuclear pore localization motif. The 3' end of this gene is similar to the last 4 exons of the zona pellucida glycoprotein 3 (ZP3) gene and the encoded protein retains one zona pellucida domain. Multiple protein isoforms are encoded by transcript variants of this gene. [provided by RefSeq, Jul 2008]
Function:
The mammalian zona pellucida, which mediates species-specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix formation.
Subcellular Location:
Secreted > extracellular space > extracellular matrix and Cell membrane.
Tissue Specificity:
Expressed in spleen, thymus, pancreas, testis, ovary, small intestine, colon and lymphocytes.
Post-translational modifications:
Proteolytically cleaved before the transmembrane segment to yield the secreted ectodomain incorporated in the zona pellucida.
N-glycosylated.
O-glycosylated; removal of O-linked glycans may play an important role in the post-fertilization block to polyspermy.
SWISS:
Q6PJE2
Gene ID:
22932
Database links:
Entrez Gene: 22932 Human
Omim: 600587 Human
SwissProt: Q6PJE2 Human
Unigene: 488877 Human
Unigene: 712837 Human
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