This gene encodes one of the protein subunits of the small nucleolar ribonucleoprotein complexes: the endoribonuclease for mitochondrial RNA processing complex and the ribonuclease P complex. The encoded protein is localized to the nucleus and associates directly with the RNA component of these complexes. This protein is involved in processing of precursor RNAs. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2009]
Function:
Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. May function with RPP38 to coordinate the nucleolar targeting and/or assembly of RNase P.
Subunit:
Component of nuclear RNase P and RNase MRP ribonucleoproteins. RNase P consists of an RNA moiety and at least 8 protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38 and RPP40. RNase MRP consists of an RNA moiety and at least 9 protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38, RPP40, POP5 and RPP21. Interacts with RPP25 and POP5.
Subcellular Location:
Nucleus; nucleolus.
Similarity:
Belongs to the eukaryotic/archaeal RNase P protein component 1 family.
SWISS:
O95707
Gene ID:
10775
Database links:
Entrez Gene: 614870 Cow
Entrez Gene: 10775 Human
Entrez Gene: 66161 Mouse
Entrez Gene: 292831 Rat
Entrez Gene: 553787 Zebrafish
Omim: 606114 Human
SwissProt: Q2KIB9 Cow
SwissProt: O95707 Human
SwissProt: Q9CR08 Mouse
SwissProt: Q5M882 Rat
Unigene: 412870 Human
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