This gene encodes a protein with protease activity and is expressed in the placenta. The protein may be useful as a tumor marker. Multiple alternatively spliced transcript variants have been found for this protein. [provided by RefSeq, Feb 2010]
Function:
Endoribonuclease that cleaves single-stranded RNAs at uridylates and releases products that have 2'-3'-cyclic phosphate termini.
Subcellular Location:
Secreted.
Tissue Specificity:
Placental-specific, but also associated with various malignant neoplasms.
Post-translational modifications:
It has been suggested that the active SMB domain may be permitted considerable disulfide bond heterogeneity or variability, thus two alternate disulfide patterns based on 3D structures are described with 1 disulfide bond conserved in both.
Similarity:
Belongs to the ENDOU family.
Contains 2 SMB (somatomedin-B) domains.
SWISS:
P21128
Gene ID:
8909
Database links:
Entrez Gene: 525399 Cow
Entrez Gene: 8909 Human
Entrez Gene: 19011 Mouse
Entrez Gene: 136317 Rat
Omim: 606720 Human
SwissProt: A6QLQ8 Cow
SwissProt: P21128 Human
SwissProt: Q3V188 Mouse
Unigene: 997 Human
Unigene: 1001 Mouse
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