The protein encoded by this gene is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. It has been proposed that liprins are multivalent proteins that form complex structures and act as scaffolds for the recruitment and anchoring of LAR family of tyrosine phosphatases. This protein was found to interact with S100A4, a calcium-binding protein related to tumor invasiveness and metastasis. In vitro experiment demonstrated that the interaction inhibited the phosphorylation of this protein by protein kinase C and protein kinase CK2. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Function:
May regulate the disassembly of focal adhesions. Did not bind receptor-like tyrosine phosphatases type 2A.
Tissue Specificity:
Widely expressed. Absent in liver.
Similarity:
Belongs to the liprin family. Liprin-beta subfamily.
Contains 3 SAM (sterile alpha motif) domains.
SWISS:
Q86W92
Gene ID:
8496
Database links:
Entrez Gene: 101082578 Cat
Entrez Gene: 407130 Cow
Entrez Gene: 486623 Dog
Entrez Gene: 100064684 Horse
Entrez Gene: 8496 Human
Entrez Gene: 67533 Mouse
Entrez Gene: 100516194 Pig
Entrez Gene: 312855 Rat
Omim: 603141 Human
SwissProt: Q86W92 Human
SwissProt: Q8C8U0 Mouse
Unigene: 172445 Human
Unigene: 103382 Mouse
Unigene: 22871 Rat
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