This gene is a member of the cyclophilin family of peptidylprolyl isomerases. The cyclophilins are a highly conserved family, members of which play an important role in protein folding, immunosuppression by cyclosporin A, and infection of HISLV1 virions. [provided by RefSeq, Jul 2008]
Function:
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Subcellular Location:
Nucleus.
Tissue Specificity:
Abundantly expressed in kidney but has a ubiquitously low expression pattern in other adult tissues.
Similarity:
Belongs to the cyclophilin-type PPIase family.
PPIL4 subfamily.
Contains 1 PPIase cyclophilin-type domain.
Contains 1 RRM (RNA recognition motif) domain.
SWISS:
Q8WUA2
Gene ID:
85313
Database links:
Entrez Gene: 85313 Human
Entrez Gene: 67418 Mouse
Omim: 607609 Human
SwissProt: Q8WUA2 Human
SwissProt: Q9CXG3 Mouse
Unigene: 593411 Human
Unigene: 38927 Mouse
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