Inositol phosphates (IPs) and diphosphoinositol phosphates (PP-IPs), also known as inositol pyrophosphates, act as cell signaling molecules. HISPPD1 has both IP6 kinase (EC 2.7.4.21) and PP-IP5 (also called IP7) kinase (EC 2.7.4.24) activities that produce the high-energy pyrophosphates PP-IP5 and PP2-IP4 (also called IP8), respectively (Fridy et al., 2007 [PubMed 17690096]).[supplied by OMIM, Mar 2008]
Function:
Bifunctional inositol kinase that catalyzes the formation of diphosphoinositol pentakisphosphate (InsP7 or PP-InsP5) and bi-diphosphoinositol tetrakisphosphate (InsP8 or PP2-InsP4). Converts inositolitol hexakisphosphate (InsP6) to InsP7. Also able to convert InsP7 to InsP8. Probably specifically mediates the formation of 4PP-InsP5 and 6PP-InsP5 InsP7 isomers but not of 5PP-IP5 InsP7 isomer.
Subcellular Location:
Cytoplasm > cytosol.
Tissue Specificity:
Belongs to the histidine acid phosphatase family. VIP1 subfamily.
Similarity:
Belongs to the histidine acid phosphatase family. VIP1 subfamily.
SWISS:
O43314
Gene ID:
23262
Database links:
Entrez Gene: 101091503 Cat
Entrez Gene: 780855 Cow
Entrez Gene: 488883 Dog
Entrez Gene: 100712709 Guinea pig
Entrez Gene: 100064726 Horse
Entrez Gene: 23262 Human
Entrez Gene: 227399 Mouse
Entrez Gene: 501194 Rat
Omim: 611648 Human
SwissProt: O43314 Human
SwissProt: Q6ZQB6 Mouse
Unigene: 212046 Human
Unigene: 220817 Mouse
Unigene: 417682 Mouse
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