This gene encodes a member of the ZIP family of metal ion transporters. The encoded protein functions as a zinc transporter. Mutations in this gene may be associated with susceptibility to carotid artery disease. Multiple transcript variants have been described. [provided by RefSeq, Mar 2010]
Function:
Mediates zinc uptake. Zinc uptake may be mediated by a Zn(2+)-HCO(3)(-) symport mechanism and can function in the presence of albumin. May also transport other divalent cations. May be important in contact inhibition of normal epithelial cells and loss of its expression may play a role in tumorigenesis.
Subcellular Location:
Cell membrane.
Tissue Specificity:
Expressed only in prostate and uterine epithelial cells.
Similarity:
Belongs to the ZIP transporter (TC 2.A.5) family.
SWISS:
Q9NP94
Gene ID:
214922
Database links:
Entrez Gene: 29986 Human
Entrez Gene: 214922 Mouse
Entrez Gene: 305846 Rat
Omim: 612166 Human
SwissProt: Q9NP94 Human
SwissProt: Q2HIZ9 Mouse
SwissProt: D3ZIN1 Rat
Unigene: 175783 Human
Unigene: 281343 Mouse
Unigene: 51972 Rat
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