System L amino acid transporters, such as SLC43A2, mediate sodium-independent transport of bulky neutral amino acids across cell membranes (Bodoy et al., 2005 [PubMed 15659399]).[supplied by OMIM, Mar 2008]
Function:
Sodium-, chloride, pH-independent high affinity transport of large neutral amino acids.
Subcellular Location:
Membrane.
Tissue Specificity:
Detected in several tissues with, higher expression in placenta, kidney and peripheral blood leukocytes. In the kidney is detected in epithelial cells of the distal tubule and collecting duct. In the intestine is expressed mainly in crypt cells of the intestinal microvilli ans epithelial cells in the base of the villus.
Post-translational modifications:
Glycosylated.
Similarity:
Belongs to the SLC43A transporter (TC 2.A.1.44) family.
SWISS:
Q8N370
Gene ID:
124935
Database links:
Entrez Gene: 491193 Dog
Entrez Gene: 100072377 Horse
Entrez Gene: 124935 Human
Entrez Gene: 100623009 Pig
Entrez Gene: 100342229 Rabbit
Entrez Gene: 287532 Rat
Omim: 610791 Human
SwissProt: Q8N370 Human
Unigene: 160550 Human
Unigene: 204988 Rat
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