This gene encodes a nuclear protein expressed in a variety of tissues. Expression of this gene has been shown to be repressed by B-cell CLL/lymphoma 6 (BCL6), a transcriptional repressor required for lymph node germinal center development, suggesting that BCL6 regulates apoptosis by its effects on this protein. Alternative splicing results in multiple transcript variants and pseudogenes have been identified on chromosomes 9 and 12. [provided by RefSeq, Dec 2010]
Function:
May be a DNA-binding protein with a regulatory function. May play an important role in cell death and/or in regulation of cell proliferation.
Subcellular Location:
Nucleus.
Tissue Specificity:
Ubiquitous.
Similarity:
Contains 1 MYND-type zinc finger.
SWISS:
Q16342
Gene ID:
5134
Database links:
Entrez Gene: 5134 Human
Entrez Gene: 18567 Mouse
Entrez Gene: 58934 Rat
SwissProt: Q16342 Human
SwissProt: P46718 Mouse
SwissProt: P47816 Rat
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