This gene encodes a member of the phosducin-like protein family and is a putative modulator of heterotrimeric G proteins. The protein shares extensive amino acid sequence homology with phosducin. Members of the phosducin-like protein family have been shown to bind to the beta-gamma subunits of G proteins. [provided by RefSeq, Jul 2008]
Function:
Modulates the activation of caspases during apoptosis. Is a substrate for Orgyia pseudotsugata multicapsid polyhedrosis virus (OpMNPV) IAP-mediated ubiquitination.
Subcellular Location:
Cytoplasm.
Tissue Specificity:
Expressed in all tissues examined including spleen, thymus, prostate, testis, ovary, small intestine and colon.
Similarity:
Belongs to the phosducin family.
SWISS:
Q9H2J4
Gene ID:
79031
Database links:
Entrez Gene: 79031 Human
Entrez Gene: 68833 Mouse
Entrez Gene: 316348 Rat
Omim: 611678 Human
SwissProt: Q9H2J4 Human
SwissProt: Q8BVF2 Mouse
SwissProt: Q4KLJ8 Rat
Unigene: 469459 Human
Unigene: 28121 Mouse
Unigene: 10647 Rat
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