Cyclic nucleotide phosphodiesterases (PDEs) catalyze hydrolysis of the cyclic nucleotides cAMP and cGMP to the corresponding nucleoside 5-prime-monophosphates. Mammalian PDEs have been classified into several families based on their biochemical properties. Members of the PDE1 family, such as PDE1C, are calmodulin (see MIM 11436)-dependent PDEs (CaM-PDEs) that are stimulated by a calcium-calmodulin complex (Repaske et al., 1992 [PubMed 1326532]).[supplied by OMIM, Oct 2009]
Function:
Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a high affinity for both cAMP and cGMP.
Subcellular Location:
Cytoplasm.
Tissue Specificity:
Expressed in several tissues, including brain and heart.
Similarity:
Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.
SWISS:
Q14123
Gene ID:
5137
Database links:
Entrez Gene: 5137 Human
Entrez Gene: 18575 Mouse
Entrez Gene: 81742 Rat
Omim: 602987 Human
SwissProt: Q14123 Human
SwissProt: Q64338 Mouse
SwissProt: Q63421 Rat
Unigene: 728862 Human
Unigene: 5145 Mouse
Unigene: 10289 Rat
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