The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE4 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]
Function:
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.
Tissue Specificity:
Expressed in various tissues but not in cells of the immune system.
Similarity:
Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.
SWISS:
Q08493
Gene ID:
5143
Database links:
Entrez Gene: 5143 Human
Entrez Gene: 110385 Mouse
Entrez Gene: 290646 Rat
Omim: 600128 Human
SwissProt: Q08493 Human
SwissProt: Q3UEI1 Mouse
SwissProt: P14644 Rat
Unigene: 132584 Human
Unigene: 25536 Mouse
Unigene: 214181 Rat
Unigene: 92465 Rat
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