The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE8 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011]
Function:
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development.
Tissue Specificity:
Expressed in most tissues except thymus and peripheral blood leukocytes. Highest levels in testis, ovary, small intestine and colon.
Similarity:
Belongs to the cyclic nucleotide phosphodiesterase family.
PDE8 subfamily.
Contains 1 PAC (PAS-associated SLCterminal) domain.
Contains 1 PAS (PER-ARNT-SIM) domain.
SWISS:
O60658
Gene ID:
5151
Database links:
Entrez Gene: 5151 Human
Entrez Gene: 18584 Mouse
Entrez Gene: 308776 Rat
Omim: 602972 Human
SwissProt: O60658 Human
SwissProt: O88502 Mouse
Unigene: 9333 Human
Unigene: 371577 Mouse
Unigene: 24771 Rat
|
|
